After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday's game vs. Miami. Guerendo is dealing with a hamstring injury and is unlikely to play, per source. pic.twitter.com/PyqyBCqPoT

The story of the San Francisco 49ers season may be perfectly summarized by their struggles in the offensive backfield. Injuries have plagued them since training camp when running back Christian McCaffrey was shut down because of Achilles tendinitis that wound up costing

Here are our experts' predictions for this Week 16 showdown. The 49ers are favorites to defeat the Dolphins, according to the BetMGM NFL odds. Not interested in this game? Check out expert picks and best bets for every NFL game this week. NFL STATS CENTRAL ...

SportsLine's model simulated the San Francisco 49ers vs. Los Angeles Rams on Thursday Night Football 10,000 times and revealed its NFL best bets

The San Francisco 49ers suspended De'Vondre Campbell three games after the linebacker refused to enter the game against the Los Angeles Rams on

It's not often that you get NFL coaches or even executives willing to admit that a particular signing was a mistake, but a situation with the San Francisco 49ers has created a rare exception for head coach Kyle Shanahan.

The San Francisco 49ers may be without the services of one of their top players for the final three games of the season.

The Indianapolis Colts claimed cornerback Ambry Thomas on waivers, according to ESPN’s Adam Schefter. Thomas is a former third-round selection by the San Francisco 49ers in the 2021 NFL draft and had spent his career there up until recently.

The San Francisco 49ers on Tuesday as part of a slew of roster moves waived former third-round pick Ambry Thomas. Thomas, a cornerback from the University of Michigan, was claimed Wednesday by the Ind