History has shown us that divisional matchups could end up closer than expected, but you couldn't tell that from many of the Week 16 NFL odds. Bills vs. Patriots has Buffalo favored by 14 points in the largest of the Week 16 NFL lines and one of the biggest NFL spreads of the season.

Broncos can clinch a playoff berth with a win over the Chargers. Plus, Eagles and Vikings have stiff tests as they battle for the top seed in the NFC.

The Vikings have seen their defensive prowess slip in the second half of the schedule but remain relentless in their pursuit of pressure. Defensive coordinator Brian Flores dials up the blitz more than any team in the NFL, which has boiled down to the fourth-highest pressure rate and 42 sacks on the season (tied for fourth).