After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the ...

Guerendo has rushed for 381 yards and four touchdowns this season. The 49ers are also likely to again be without left tackle ...

Mike Florio and Chris Simms discuss how the 49ers could possibly make some noise this Sunday against the Dolphins, despite ...

Isaac Guerendo #31 of the San Francisco 49ers warms up before a game against the Seattle Seahawks at Levi's Stadium on ...

49ers fans invaded Buffalo, NY, to rally against the Bills for "Sunday Night Football".Fans enjoyed giveaway items, a raffle and Zenni Kittle Collection glasses, presented by Zenni.

The 49ers have gotten used to being shorthanded at running back this season and it looks like they'll be down another one in ...