After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the ...

The San Francisco 49ers are going to have a fourth different starting running back this season according to a report from ...

San Francisco 49ers running back Isaac Guerendo is unlikely to play in Sunday's game against the host Miami Dolphins, ESPN ...

After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the ...

San Francisco 49ers running back Isaac Guerendo is "unlikely to play" against the Miami Dolphins, according to ESPN insider ...

Hall of Fame quarterback Kurt Warner wasn't keen on the rumors flying around about flipping Brock Purdy for Sam Darnold next ...

Deommodore Lenoir parlayed his rare skill as Mr. Inside and Mr. Outside into a five-year contract worth $92 million.

San Francisco will have a series of franchise-altering decisions to make when the 2025 offseason arrives. Among those are ...

It was after a Bills fans takeover in Seattle in October. That day, Buffalo quarterback Josh Allen was laughing and ...

Shutting down Williams would make sense given that the 49ers are virtually eliminated from the postseason. He turns 37 before ...

San Francisco coach Kyle Shanahan said the team is getting close to ruling out star left tackle Trent Williams for the rest ...

The San Francisco 49ers may be without the services of one of their top players for the final three games of the season.